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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada
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We take a multisystem approach

Neuroendocrine

6 Neuroendocrine Studies
"Neuroendocrine" refers to the interactions between the nervous system which controls body functions through nerve impulses, and the endocrine system that regulates body functions through hormones.

Immune

3 Immune Studies
The immune system defends the body against infections and diseases, helping to maintain overall health.

Cardiovascular

3 Cardiovascular Studies
The cardiovascular system, comprising the heart, blood vessels, and blood, is responsible for transporting oxygen, nutrients, hormones, and waste products throughout the body.

Metabolism

10 Metabolism Studies
Multiomics is a scientific approach that can include genomics, proteomics, metabolomics, and transcriptomics to get a comprehensive understanding of biological systems. Abnormalities in carbohydrate, lipid, and amino acid metabolism have been observed.

Genetics

1 Genetics Study
Genetics may contribute to an individual's susceptibility to multisystem disease, including variations in immune system genes, genes involved in energy metabolism, and genes related to neurotransmitter function.

Multiomics

12 Multi Omics Studies
Multiomics combines various omics technologies such as genomics, transcriptomics, and proteomics.

Diagnostics

11 Diagnostic Studies
Diagnostic studies will help identify specific biomarkers towards differentiating between ME/CFS and illnesses with similar clinical presentations.,

 

Treatment

2 Treatment Studies
Treatment studies evaluate the efficacy and safety of potential interventions. Focusing on repurposed drugs could quickly provide evidence-based guidelines for healthcare providers.

 

Systems Biology

4 Systems Biology Studies
Systems biology is an interdisciplinary approach that can help identify key pathways, biomarkers, and potential therapeutic targets.

Pathogens

4 Pathogen Studies
Infections can trigger or worsen a wide range of symptoms.

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Studies funded by OMF

since 2012

By funding studies that examine multiple systems, researchers can see how ME/CFS and Long COVID develop. This approach will lead to more effective treatments and improved quality of life.

Click on each system to read a description.

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.